Controlled trial of propranolol to prevent recurrent variceal bleeding in patients with non-cirrhotic portal fibrosis.
نویسنده
چکیده
Fifty patients with non-cirrhotic portal fibrosis who were admitted to hospital because of upper gastrointestinal bleeding were randomly assigned to treatment with either oral propranolol given in doses that reduced the resting pulse rate by 25% (25 patients) or with a placebo (25 patients). One year after the start of the study 20 patients in the propranolol group and five patients in the placebo group were free from recurrent gastrointestinal bleeding (p less than 0.0001). Giving continuous oral propranolol treatment is therefore effective in preventing recurrent upper gastrointestinal bleeding in patients with non-cirrhotic portal fibrosis.
منابع مشابه
Precipitation of hepatic encephalopathy by propranolol in cirrhosis.
Continuous oral propranolol reduces portal venous pressure in patients with cirrhosis.' A controlled trial in such patients who had bled from varices showed a significantly lower incidence of rebleeding in those given propranolol.2 This led to the widespread and enthusiastic use of propranolol to prevent recurrent variceal haemorrhage in patients with cirrhosis. The beneficial effect of propran...
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ورودعنوان ژورنال:
- BMJ
دوره 298 6684 شماره
صفحات -
تاریخ انتشار 1989